• Nevertheless the frequency of CTCs was higher in patients

  2021-10-14

  

  Nevertheless, the frequency of CTCs was higher in patients with metastatic breast cancer, which is to be expected because cancer Annexin V-EGFP Apoptosis Kit from the original clone that caused the metastasis probably had features favoring their spread throughout the body. When we take HER2+ CTC co

• Ras small GTPases are critical

  2021-10-14

  

  Ras small GTPases are critical molecular switches that connect extracellular signals to intracellular signaling pathways initiated by membrane receptors, such as growth factor receptors and G protein-coupled receptors (Simanshu et al., 2017). When shifting between active GTP-bound and inactive GDP-b

• Among the GSK inhibitors available

  2021-10-14

  

  Among the GSK-3 inhibitors available in market, lithium is probably the only example and the oldest one. Some molecules, both natural and synthetic, such as maleimide derivatives, staurosporine (from the bacterium Streptomyces storosporeus), indole derivatives such as indirubin (used since long in t

• Several studies have proposed that high levels of

  2021-10-14

  

  Several studies have proposed that high levels of KYNA in the somatostatin receptor contribute to cognitive dysfunctions presented by patients who suffer from schizophrenia [30], [31], [32], [33]. Considering that: (i) KYNA is a known GPR35 agonist [2], (ii) cognitive impairments in patients with sc

• br Animal models of NASH The human

  2021-10-14

  

  Animal models of NASH The human NAS system (see above) is largely reproducible in NAFLD mouse models [37] and, therefore, has been increasingly applied in the preclinical assessment of liver histological responses to test compounds. In general, the NAS system is well suited for this purpose, alth

• br Materials and methods br Results br

  2021-10-14

  

  Materials and methods Results Discussion Heart hypertrophy is initially physiological to compensate for the loss of heart functions. However, sustained stresses lead to a pathological status, in which myocardium becomes stiffened by interstitial fibrosis and thereby diastolic dysfunction in

• br Materials and methods br

  2021-10-14

  

  Materials and methods Results Discussion The glucose transporter GLUT1 can be acutely activated or inhibited in L929 fibroblast MRS 1220 by a wide variety of reagents or nutrient conditions [[9], [10], [11], [12],36,50]. This abrupt change in the activity of GLUT1 occurs within minutes and

• The observed increase in macroscopic conductance

  2021-10-14

  

  The observed increase in macroscopic conductance could be due to a left shift in the open state probability vs. voltage curve for the high-activity state causing an increase in the open state probability at all potentials. However, an increase of the apparent single channel conductance cannot be ent

• In summary this study demonstrated the cDNA cloning and char

  2021-10-14

  

  In summary, this study demonstrated the cDNA cloning and characterization of the galanin type II receptor (GalR2) and a novel GalR2-like receptor (GalR2-L) in chickens, in which these two receptors are possibly originated from a gene CMX001 australia event that occurred in the early vertebrate line

• At the present time there are several clinical trial studies

  2021-10-13

  

  At the present time, there are several clinical trial studies being conducted with a variety of indications for pitolisant. Various studies in different phases assess different aspects of pitolisant efficacy and safety in narcoleptic patients (Szakacs et al., 2017) (NCT01800045, NCT02611687, NCT0343

• br Discussion In this study we show that

  2021-10-13

  

  Discussion In this study, we show that conditional loss of Yap/Taz in the endocardium results in a thin compact myocardium and early postnatal lethality. We also report that loss of Yap/Taz in the endocardium leads to diminished expression of Nrg1, which is a crucial endocardial-derived factor th

• br Conclusion and prospect Small GTPases are very

  2021-10-13

  

  5. Conclusion and prospect Small GTPases are very important regulatory proteins of eukaryotes. They play crucial regulatory function in various movement processes of organism [75], [76], [77]. Different nanoparticles used to investigate the interaction with small GTPases inside L-745,870 trihydro

• br Materials and methods br Results br Discussion

  2021-10-13

  

  Materials and methods Results Discussion Main results obtained in this work are presented in Table 1 and can be summarized as follows: 1) AEA inhibits FcεRI receptor-induced degranulation with the participation of CB2 and GPR55 receptors by a PTX-insensitive mechanism; 2) AEA does not block

• Our study has some limitations that

  2021-10-13

  

  Our study has some limitations that should be considered when the results are interpreted. First, we did not measure the protein levels of Bax and Bcl2, due to time and budget limitations. Although simultaneous measurements of both mRNA and protein levels are complementary for a better understanding

• So far the functional significance of GluR A and GluR

  2021-10-13

  

  So far, the functional significance of GluR-A and GluR-B in synaptic plasticity has been best studied in the context of long-term potentiation of synaptic transmission in vitro in the hippocampus and the regulation of synaptic strength in paradigms underlying activity-dependent learning in vivo Taka

14386 records 542/960 page Previous Next First page 上5页 541542543544545 下5页 Last page