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The purposes of this study is to develop an experimental
2019-09-03
The purposes of this study is to develop an experimental model of CysLT2 receptor-mediated LTC4-induced lung air-trapping in guinea pigs using S-hexyl GSH, and to clarify the mechanism underlying response to such trapping using montelukast, a CysLT1 receptor antagonist, BayCysLT2RA, a CysLT2 recept
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Currently approved anti obesity drugs for long term
2019-09-03
Currently approved anti-obesity drugs for long term use such as orlistat, lorcaserin and liraglutide are efficient in reduction of weight gain but are limited in usage due to their adverse effect profile and higher cost (Krentz et al., 2016; Mopuri and Islam, 2017). In 9-AC pathway to this, plant d
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Kim et al reported for bioactive compounds originating
2019-09-03
Kim et al. reported for bioactive compounds originating from the endemic species in Korea, the hexane and EtOAc fractions of the MeOH extracts from the roots of Dystaenia takeshimana (Nakai) Kitagawa (Umbelliferae) showed cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) dual inhibitory activity b
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POE specialises Rogers definition of engineering to systems
2019-09-03
POE specialises Rogers\' definition of engineering [37] to systems engineering as: As such, systems engineering becomes a problem solving exercise, the problem being, given a physical environment E, to find the system S that p2x7 antagonist meets a real-world need N to the satisfaction of a group o
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To our knowledge this study is the first
2019-09-03
To our knowledge, this study is the first to construct a whole-body transcriptome of D. variabilis. Most of the data currently accessible in NCBI are derived from a midgut EST database consisting of 1679 transcripts (Anderson et al., 2008) and about 20,000 mRNA sequences from the testis-vas deferens
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Analysis of DNA fragmentation We
2019-09-03
Analysis of DNA fragmentation. We followed a modified Hirt extraction procedure for analysis of DNA fragmentation. Cells were suspended in TNE buffer (1M NaCl, 20mM Tris–HCl, pH 7.4, 2mM EDTA, and 0.6% SDS) at a density of 106 cells/ml and incubated overnight on ice. The next day, cellular debris wa
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In countries such as China where there is
2019-09-03
In countries such as China where there is a high commercial production of rice, the use of rice husk ash (RHA) as an alternative cementing material can become a great asset for environmental rehabilitation and address the difficult disposal issues associated with this agricultural waste [23]. RHA po
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br Results br Discussion In
2019-09-03
Results Discussion In this paper we present insights into the observed specificities of inhibitors targeting the ubiquitin-activating and related E1 aromatase inhibitors via crystal structures of the specific NEDD8-E1 inhibitor MLN4924, the dual NEDD8/Ub E1 inhibitor ABPA3, and the selective U
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FAK Inhibitor 14 br Materials and methods br Results
2019-09-03
Materials and methods Results We examined the effects of curcumin in Fluo-4 loaded SH-EP1 FAK Inhibitor 14 stably transfected with human α7-nACh receptor. Application of curcumin alone in the concentrations up to 100 μM for 30 sec. did not induce any detectable change in intracellular Ca2+ le
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br Materials and methods br Results and
2019-09-03
Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic MC 1568 is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacteria such as Lactobacillus plantar
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In regards to regional variation
2019-09-03
In regards to regional variation in metabolic behavior of adipose tissue, subcutaneous adipose tissue transplantation has been shown to reprogram visceral adipose tissue to have subcutaneous-like phenotypic behavior, whereas visceral-to-subcutaneous transplantation does not promote a more detrimenta
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br DDR mediated signaling DDRs initiate signaling pathways i
2019-09-03
DDR-mediated signaling DDRs initiate signaling pathways in a context and cell type-dependent manner. For instance, DDR1 was reported to activate ERK in vascular smooth muscle 5 03 (Lu et al., 2011), to inhibit ERK in mesangial cells (Curat and Vogel, 2002), and to have no effect on ERK activation
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Neuronal cells have highly developed ER which makes them
2019-09-03
Neuronal CHC have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-like endo
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br Conclusions br Acknowledgements This work
2019-09-03
Conclusions Acknowledgements This work was supported by the Science and Technology Planning Projects of Guangdong Province (2014A020210027); the Major Scientific Research Projects of Universities in Guangdong Province (2016KZDXM042); the Natural Science Foundation of Guangdong Province (2015A0
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Ginsenoside Re lysine mixture had increased anticancer effec
2019-09-03
Ginsenoside Re-lysine mixture had increased anticancer effects upon heat processing by regulating Bcl-2 and Bax (Yamabe et al., 2013). Ginsenoside Re (20mg/kg) inhibited NF-κB activation by inhibiting LPS binding to TLR4 on macrophages in TNBS-treated mice (Lee, Hyam, Jang, Han, & Kim, 2012). The ch
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